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pentobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers could boost the metabolism of ifosfamide to its Energetic alkylating metabolites.pentobarbital will lessen the level or result of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Mon